Synthesis, characterisation, crystal structure and anti. Synthesis, structural elucidation and cytotoxicity of new. In iraq like most third world countries, attempts discovered new antibiotic drugs derived from thiosemicarbazide and its metal complexes and developed the branch of applied in organic chemistry. In recent years, we have been working on the synthesis of heterocyclic thiosemicarbazone, their metal complexes and biological activities 12. Sample records for acetophenone thiosemicarbazones synthesis the complex compounds of rhenium with methyl ident thiosemicarbazone were synthesized. Synthesis, characterization and biocidal properties of platinum metal complexes derived from 2,6diacetylpyridine bis thiosemicarbazone monika tyagi, sulekh chandra.
Thiosemicarbazone article about thiosemicarbazone by the. New z2pyrrolidin2ylidenehydrazinecarbothioamide l was synthesized in a good yield by the reaction of pyrrolidone with thiosemicarbazide. Thiosemicarbazone definition of thiosemicarbazone by. Nitroprusside was chosen in order to test if its ability to release no can increase the biological activity already shown by these complexes. Copperii and cobaltiii pyridoxal thiosemicarbazone. Preferential inhibition of ribonucleic acid synthesis by a. Polystyrene ps obtained from styrofoam waste was acetylated and then condensed to pts by reacting it with 4phenyl3thiosemicarbazide ligand and characterized by ftir spectroscopy and elemental analysis. Synthesis, molecular structure and antibacterial activity of. Tomma2 1department of chemistry, college of science, university of almustansiriyah, baghdad, iraq.
Synthesis and antimicrobial activity of tetradentate ligands bearing hydrazone andor thiosemicarbazone motifs and their diorganotiniv complexes. Synthesis and characterization of some novel 4thiazolidinones and isoxazolines derived from thiosemicarbazones ahmed n. Pages in category thiosemicarbazone the following 6 pages are in this category, out of 6 total. Synthesis of thiosemicarbazone and 4thiazolidinone derivatives and their in vitro antitoxoplasma gondii activity. Due to the wellknown coordination chemistry of gallium, high stability of ga.
To this apparatus and libinda digital melting point apparatus expressed in c and experimental all the chemicals were purchased from fluka and ranchem. Synthesis, characterisation, crystal structure and anticorrosion studies of an organotiniv complex of 2acetylpyridine 4ethyl3 thiosemicarbazone lh. May 24, 2014 in the present work, we report the synthesis and systematic evaluation of differently substituted semicarbazones and thiosemicarbazones on lysosomal cysteine protease, cathepsin b 3. Synthesis, structure and electrochemical properties of some. Synthesis, spectroscopic study and crystal structures potential anticancer drugs. Given this context, our group has been testing several synthetic compounds of the thiosemicarbazone class. Synthesis, characterization, theoretical crystal structure. Thiosemicarbazone derivatives have found application in drug development for the treatment of central nervous system disorders, of bacterial infection, as well as analgesic and antiallergic agent.
Pdf synthesis, structural elucidation and cytotoxicity. A compound containing the thiosemicarbazide radical, nnhcsnh 2. Synthesis and spectral investigations of some platinum metals ions coordination compounds of 4nfuran2. Synthesis of benzylmethyl4methyl3 thiosemicarbazone. General method for the synthesis of 2amino5aryl1, 3, 4thiadiazole1620 compound i 0. Among the differently functionalized semicarbazones 1a1j and thiosemicarbazones 2a2j. Molecules free fulltext synthesis and evaluation of new. Synthesis and characterization of criii complexes with thiosemicarbazone and semicarbazone based ligands sulekh chandra 1 2,smriti raizada, sangeeta sadwal2 1 department of chemistry, zakir husain delhi college, university of delhi, jawaharlal nehru marg, new delhi, india. Semicarbazone are the schiff bases, usually obtained by condensation of semicarbazide with suitable aldehydes and ketones fig1. The work presented in the book entitled an approach to study of thiosemicarbazone and their transition metal complexes can be summarizes the preparation and structure characterization of various thiosemicarbazones attached pyrazol aldehyde as well as their metal complexes. Zincii complexes of 2acetyl pyridine 14fluorophenylpiperazinyl thiosemicarbazone.
Synthesis at 37 a series of the halo substituted thiosemcarbazone ligands 1, 2and 3 poured on to the agar medium in an agar plate maintained at 40are synthesized by using a modified procedure metwallyet al. To the hot ethanolic solution of thiosemicarbazide, the. Functionalized bisthiosemicarbazonato complexes of zinc. Thiosemicarbazone h caused bacteriostasis and a primary inhibition of ribonucleic acid synthesis. In this paper the syntheses of new pyridoxal thiosemicarbazone copperii and cobaltiii complexes with nitroprusside as a counterion and tests on the antileukemic activity of three of these complexes toward human cell lines u937 and cem are reported. One of a group of tuberculostatic drugs that includes thiosemicarbazide, benzaldehyde thiosemicarbazone, and 4aminoacetylbenzaldehyde thiosemicarbazone. When compared with the inorganic materials, organic and. In organic chemistry, a semicarbazone is a derivative of imines formed by a condensation reaction between a ketone or aldehyde and semicarbazide. Pdf synthesis, structural elucidation and cytotoxicity of. Herein, we describe the synthesis of some new thiosemicarbazone derivatives with various substitutions at terminal nitrogen r 3 as well as at the benzene ring r 1 and r 2 as shown in scheme 1, to further study this phenomenon. Synthesis of thiosemicarbazone and 4thiazolidinone. They are classified as imine derivatives because they are formed from the reaction of an aldehyde or ketone with the terminal nh 2 group of semicarbazide, which behaves very similarly to primary amines.
Thiosemicarbazone derivatives are of special importance because of their versatile biological and pharmacological activities. Chaudhary2 1department of chemistry, faculty of science, the maharaja sayajirao university of baroda, vadodara390 002,india. Addition of cooper or other transition elements was not necessary for these inhibitions. Jain, synthesis, spectral studies and antimicrobial screening of some transition metal complexes with substituted acetophenone thiosemicarbazone, international journal of pharmaceutical sciences and research, vol. Thiosemicarbazone and their complexes have received considerable attention because of their pharmacological activities. Synthesis of some novel thiosemicarbazone derivatives. Oct 25, 2019 the synthesis in carried out by stirring at the room temperature using alkali solution as catalyst and ethanol as solvent. The ruru, ruo, run and rus distances in this dinuclear complex are all quite usual, and so are the bond parameters in the coordinated ligands 2022,2428,40,41. Thiosemicarbazone psubstituted acetophenone derivatives promote the loss of mitochondrial, gsh depletion, and death in k cells. Preferential inhibition of ribonucleic acid synthesis by a new thiosemicarbazone possessing antibacterial and antiparasitic properties item. Synthesis and evaluation of some semicarbazone and.
Synthesis of co 9 s 8 and cos nanocrystallites using coii. New benzodioxolebased thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on a549 human lung adenocarcinoma, c6 rat glioma and nih3t3 mouse embryonic fibroblast cells. Nov 26, 2015 cubic co9s8 and hexagonal cos nanocrystallites were prepared by pyrolysis and solvothermal decomposition methods using colh2cl2 and col2 where lh thiosemicarbazones of furfuraldehyde, cinnamaldehyde and 4fluoroacetophenone as singlesource precursors. As part of our ongoing studies, in this paper, we describe synthesis, ir, how to cite this paper.
Synthesis and in vitro evaluation of goldi thiosemicarbazone complexes for antimalarial activity. Department of chemistry, zakir husain delhi college, university of delhi, new delhi, india. Novel synthesis and characterization of thiosemicarbazone. Synthesis, characterization and antimicrobial studies on. New halogenated thiosemicarbazones as potential antimicrobial. Antiretroviral activity of thiosemicarbazone metal complexes. Synthesis and characterization of criii complexes with. The thiosemicarbazone ligands, 4pmethoxyphenylthiosemicarbazone of ohydroxynapthaldehyde h 2 l 1, 4pmethoxyphenylthiosemicarbazone of benzoyl pyridine hl 2 and 4pchlorophenylthiosemicarbazone of ovanillin h 2 l 3 were prepared by following a reported procedure 15b,20. Thiosemicarbazones have been found to inhibit cathepsin b activity to a greater extent than semicarbazones. Semicarbazone definition of semicarbazone by medical dictionary. An attempt has been made to recycle styrofoam waste to a novel functional polymer, phenyl thiosemicarbazone surface pts. In order to examine the correlation between anticancer activity and cholinesterases, the compounds were evaluated for their inhibitory effects on ache and buche. An approach to study of thiosemicarbazone and their metal.
Thiosemicarbazones display a wide antimicrobial activity by targeting bacteria, fungi, and viruses. Whereas sulfato complex was found to have five coordinate trigonalbipyramidal geometry. Synthesis, characterization and biocidal properties of. Synthesis of some novel thiosemicarbazone derivatives having. Synthesis and anticonvulsant screening of some novel 1, 3, 4. These nanocrystallites were characterized by powder xray diffraction, scanning electron microscopy, transmission electron microscopy. Synthesis, characterization and antimicrobial studies on bivalent copper, nickel and cobalt complexes of thiosemicarbazone a. Iiisemicarbazone in comparison with its thiosemicarbazone complexes 4, and its enhanced antineoplastic activity, we were interested in developing new radiotracers with favorable biochemical properties. Synthesis, characterization and biocidal properties of platinum metal complexes derived from 2,6diacetylpyridine bis thiosemicarbazone abstract fulltext html download as pdf size. Synthesis, characterization, and in vitro anticancer activity of copper and zinc bis thiosemicarbazone complexes. Here, we report our studies on the antiviral activity of two thiosemicarbazone metal complexes, biscitronellalthiosemicarbazonatonickelii and aquapyridoxalthiosemicarbazonatocopperii chloride monohydrate, against the retroviruses hiv1 and htlv12.